Inhibition of Orai1-mediated Ca entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle
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چکیده
Sarah König, Sara Browne, Bernhard Doleschal, Michaela Schernthaner, Michael Poteser, Heinrich Mächler, Eric Wittchow, Marlen Braune, Martin Muik, Christoph Romanin, and Klaus Groschner Institute of Biophysics, Medical University of Graz, Graz, Austria; Department of Cardiac Surgery, Medical University of Graz, Graz, Austria; Vascular Interventions Research and Deleopment Group, Biotronik Societas Europaea and Compagnie Kommanditgesellschaft, Erlangen, Germany; and Institute of Biophysics, University of Linz, Linz, Austria
منابع مشابه
Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.
Sirolimus (rapamycin) is used in drug-eluting stent strategies and proved clearly superior in this application compared with other immunomodulators such as pimecrolimus. The molecular basis of this action of sirolimus in the vascular system is still incompletely understood. Measurements of cell proliferation in human coronary artery smooth muscle cells (hCASM) demonstrated a higher antiprolifer...
متن کاملOrai1, a critical component of store-operated Ca entry, is functionally associated with Na /Ca exchanger and plasma membrane Ca pump in proliferating human arterial myocytes
Baryshnikov SG, Pulina MV, Zulian A, Linde CI, Golovina VA. Orai1, a critical component of store-operated Ca entry, is functionally associated with Na /Ca exchanger and plasma membrane Ca pump in proliferating human arterial myocytes. Am J Physiol Cell Physiol 297: C1103–C1112, 2009. First published August 12, 2009; doi:10.1152/ajpcell.00283.2009.—Ca entry through store-operated channels (SOCs)...
متن کاملOrai1, a critical component of store-operated Ca2+ entry, is functionally associated with Na+/Ca2+ exchanger and plasma membrane Ca2+ pump in proliferating human arterial myocytes.
Ca(2+) entry through store-operated channels (SOCs) in the plasma membrane plays an important role in regulation of vascular smooth muscle contraction, tone, and cell proliferation. The C-type transient receptor potential (TRPC) channels have been proposed as major candidates for SOCs in vascular smooth muscle. Recently, two families of transmembrane proteins, Orai [also known as Ca(2+) release...
متن کاملPDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.
Platelet-derived growth factor (PDGF) and its receptor are known to be substantially elevated in lung tissues and pulmonary arterial smooth muscle cells (PASMC) isolated from patients and animals with pulmonary arterial hypertension. PDGF has been shown to phosphorylate and activate Akt and mammalian target of rapamycin (mTOR) in PASMC. In this study, we investigated the role of PDGF-mediated a...
متن کاملStim1- and Orai1-mediated store-operated calcium entry is critical for angiotensin II-induced vascular smooth muscle cell proliferation.
AIM Despite the fact that angiotensin (Ang) II is a critical regulator of the proliferation and migration of vascular smooth muscle cells (VSMCs), the effect of Ang II on VSMC proliferation has remained unclear. In this study, we determined whether Stim1- and Orai1-mediated store-operated calcium (Ca(2+)) entry (SOCE) plays a critical role in Ang II-induced VSMC proliferation and Ang II-acceler...
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تاریخ انتشار 2013